, 2006; Sawaya and Kraut, 1997; Figure 1—figure nutritional supplement 1), we envisioned the mutational landscape of DHFR to get constrained with the need to undertake these unique conformations. Moreover, prior do the job experienced prompt DHFR is impacted by mobile constraints for example protein excellent Command (Bershtein et al., 2013) and the Construct-up of a poisonous metabolic intermediate (Schober et al., 2019). We consequently anticipated deep mutational scanning to reveal a very constrained mutational landscape for DHFR that could distinction With all the mutational tolerance noticed in other units.
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